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Cerulean Sonata
Procrastination at its best.
I'm just a 25 year old Vet Tech student floundering around in the big world. I'm married to one of the most wonderful men in the world, getting amped to get a really huge dog, and probably one of the shyest internet people around.
jackthemother:

lydieslittlefamily:

lightsharpnesssong:

jenova-amaranth:

fullten:

dollycoquetry:

fullten:

A lot of dudes think women dress slutty for them, but honestly if men weren’t such fucking animals I would dress 300000% more slutty then I do now. You people ruin everything.  
I wanna wear this shit outside god damn it. 

Oh my god SO TRUE. I would constantly wear thigh highs and short skirts and underbust corsets because I look so fucking good. God forbid women like their OWN bodies, too.

For real !! like 90 % of my fucking wardrobe now is just for cam cause it’s too sexy to wear in public. Fucking bullshit.  I use to wear thigh highs with garters with shorts a lot but I got sooo many comments. Fucking… people. You literally just saw the tops of my thighs. But all the dudes are like ‘Why wear that if you don’t want attention???’ cause i look fine as hell and I don’t give a shit about some fucking random broke ass dudes on the corner. 

I can’t even express how much this describes my feelings. Bitch I wear my corsets and my fishnets and my heels the size you wish your dick was because they make me feel fucking fabulous, not because I want you to tell me how much you’d like to “smash” me.

Heels the size you wish your dick was.

Omg this

This this a million times this

jackthemother:

lydieslittlefamily:

lightsharpnesssong:

jenova-amaranth:

fullten:

dollycoquetry:

fullten:

A lot of dudes think women dress slutty for them, but honestly if men weren’t such fucking animals I would dress 300000% more slutty then I do now. You people ruin everything.  

I wanna wear this shit outside god damn it. 

Oh my god SO TRUE. I would constantly wear thigh highs and short skirts and underbust corsets because I look so fucking good. God forbid women like their OWN bodies, too.

For real !! like 90 % of my fucking wardrobe now is just for cam cause it’s too sexy to wear in public. Fucking bullshit.  I use to wear thigh highs with garters with shorts a lot but I got sooo many comments. Fucking… people. You literally just saw the tops of my thighs. But all the dudes are like ‘Why wear that if you don’t want attention???’ cause i look fine as hell and I don’t give a shit about some fucking random broke ass dudes on the corner. 

I can’t even express how much this describes my feelings. Bitch I wear my corsets and my fishnets and my heels the size you wish your dick was because they make me feel fucking fabulous, not because I want you to tell me how much you’d like to “smash” me.

Heels the size you wish your dick was.

Omg this

This this a million times this

154,454 notes7.241:07 AMsource

swan2swan:

derrierebender:

Part: 1/2

Yoo Jae-myung, animation director of The Legend of Korra, discusses Nickelodeons initial hesitancy to accept Mike and Bryans proposal of the show… and Korra.

“The sequel focuses on the incarnation of the new Avatar, Korra, as she tries to save a city called the Republic City.”

“So, Korra is a young girl , not a boy. Heroes and protagonists are usually men.”

“That actually became a problem.

Nickelodeon was reluctant to produce this animated series at first because the protagonist was a girl.

I guess you could say that Americans are more conservative than Koreans.

The production was suspended just because the protagonist was a girl.

To compare this situation to a movie production, it’s as if the lead actor has already been cast, but the production agency decides to stop the filming because they don’t approve of the actor.”

Part 2: (x)

Full interview: (x)

You know what?

Flip it.

I’m blaming this. This is why we can’t have nice things. This is why we don’t get the episodes. This is why we don’t get commercials or proper advertising or merchandise. This is still prevalent, they’re still bitter about this, and their utter incompetence and ineptitude when it comes to marketing and promotion could not have POSSIBLY been the genuine reasons for this show’s troubles in the ratings, so it must have been because she’s a girl, so you see “we were right”. That’s all.

This viewpoint will continue until I have a better explanation from the studios. I don’t care if the episodes are on their website when I post this message and jump over to the site, my stance will remain the same. I want an explanation. If you’re not going to give me the product I want to invest in, I want an explanation as to why I can’t have it.

8,452 notes7.2412:21 AMsource

ask-the-multishipper:

becauseimwolfit:

catbountry:

thefrogman:

Usually when people do that “you’re special” crap I tend to roll my eyes.

But when Mister Rogers said it…

image

That’s because Mister Rogers meant it.

Mister Rogers genuinely cared about everyone and that’s why he will forever be the best. All of my feels.

True fact: He was considered to be one of the hardest people to interview, because he would turn it around and ask questions about the interviewer with genuine interest. Asking about their children and spouses, their dreams of the future, etc.

148,859 notes7.2412:19 AMsource

yazzydk101:

Jared Padalecki (and family) appreciation post..

and before you say some of them aren’t related ‘family is more then blood’

50,179 notes7.2412:18 AMsource
cleverbot:

I don’t remember this

cleverbot:

I don’t remember this

421,817 notes7.2311:50 PMsource

misbeliefs:

me starting to like someone image

295,452 notes7.2311:49 PMsource

neurosciencestuff:

Schizophrenia’s genetic skyline rising

The largest genomic dragnet of any psychiatric disorder to date has unmasked 108 chromosomal sites harboring inherited variations in the genetic code linked to schizophrenia, 83 of which had not been previously reported. By contrast, the “skyline” of such suspect variants associated with the disorder contained only 5 significant peaks in 2011. By combining data from all available schizophrenia genetic samples, researchers supported by the National Institutes of Health powered the search for clues to the molecular basis of the disorder to a new level.

“While the suspect variation identified so far only explains only about 3.5 percent of the risk for schizophrenia, these results warrant exploring whether using such data to calculate an individual’s risk for developing the disorder might someday be useful in screening for preventive interventions,” explained Thomas R. Insel, M.D., director of the NIH’s National Institute of Mental Health, one funder of the study. “Even based on these early predictors, people who score in the top 10 percent of risk may be up to 20-fold more prone to developing schizophrenia.”

The newfound genomic signals are not simply random sites of variation, say the researchers. They converge around pathways underlying the workings of processes involved in the disorder, such as communication between brain cells, learning and memory, cellular ion channels, immune function and a key medication target.

The Schizophrenia Working Group of the Psychiatric Genomic Consortium (PGC) reports on its genome-wide analysis of nearly 37,000 cases and more than 113,000 controls in the journal Nature, July 21, 2014. The NIMH-supported PGC represents more than 500 investigators at more than 80 research institutions in 25 countries.

Prior to the new study, schizophrenia genome-wide studies had identified only about 30 common gene variants associated with the disorder. Sample sizes in these studies were individually too small to detect many of the subtle effects on risk exerted by such widely shared versions of genes. The PGC investigators sought to maximize statistical power by re-analyzing not just published results, but all available raw data, published and unpublished. Their findings of 108 illness-associated genomic locations were winnowed from an initial pool of about 9.5 million variants.

A comparison of the combined study data with findings in an independent sample of cases and controls suggest that considerably more such associations of this type are likely to be uncovered with larger sample sizes, say the researchers.

There was an association confirmed with variation in the gene that codes for a receptor for the brain chemical messenger dopamine, which is known to be the target for antipsychotic medications used to treat schizophrenia. Yet evidence from the study supports the view that most variants associated with schizophrenia appear to exert their effects via the turning on and off of genes rather than through coding for proteins.

The study found a notable overlap between protein-related functions of some linked common variants and rare variants associated with schizophrenia in other studies. These included genes involved in communication between neurons via the chemical messenger glutamate, learning and memory, and the machinery controlling the influx of calcium into cells.

“The overlap strongly suggests that common and rare variant studies are complementary rather than antagonistic, and that mechanistic studies driven by rare genetic variation will be informative for schizophrenia,” say the researchers.

Among the strongest associations detected, as in in previous genome-wide genetic studies, was for variation in tissues involved in immune system function. Although the significance of this connection for the illness process remains a mystery, epidemiologic evidence has long hinted at possible immune system involvement in schizophrenia.

Findings confirm that it’s possible to develop risk profile scores based on schizophrenia-associated variants that may be useful in research – but for now aren’t ready to be used clinically as a predictive test, say the researchers.

They also note that the associated variations detected in the study may not themselves be the source of risk for schizophrenia. Rather, they may be signals indicating the presence of disease-causing variation nearby in a chromosomal region.

Researchers are following up with studies designed to pinpoint the specific sequences and genes that confer risk. The PGC is also typing genes in hundreds of thousands of people worldwide to enlarge the sample size, in hopes of detecting more genetic variation associated with mental disorders. Successful integration of data from several GWAS studies suggests that this approach would likely be transferrable to similar studies of other disorders, say the researchers.

“These results underscore that genetic programming affects the brain in tiny, incremental ways that can increase the risk for developing schizophrenia,” said Thomas Lehner, Ph.D., chief of NIMH’s Genomics Research Branch. “They also validate the strategy of examining both common and rare variation to understand this complex disorder.”

159 notes7.2311:49 PMsource
10,983 notes7.2311:48 PMsource

"Pir8te Gar8"

14,186 notes7.2311:46 PMsource
phoenix-falls:

malformalady:

Wisconsin snow storm versus flooding in Ireland

Ireland isn’t fucking around with the sealing capabilities of their doors

phoenix-falls:

malformalady:

Wisconsin snow storm versus flooding in Ireland

Ireland isn’t fucking around with the sealing capabilities of their doors

359,024 notes7.2311:45 PMsource